Infection

  • Antimicrobial, antiviral and vaccine drug discovery services
  • KWS BioTest provides real-time in vivo bioluminescent imaging using IVIS technology

We test the efficacy of your novel anti-microbials, anti-virals and vaccines using bespoke, validated in vitro, ex vivo and in vivo infection models. Our experts can adapt models to provide you with key data on specific pathogens early in your research programme to inform your decision-making.

In vitro anti-viral & anti-microbial testing

We quantify the effect of your test compounds on the growth and infectivity of a wide range of bacteria and viruses using standardised assays.

We work with many bacterial pathogens to help you to calculate the minimum inhibitory concentration (MIC) and time-kill values for your antibiotics, resistance modifiers and virulence modulators. Our in vitro team enumerate bacterial load from your in vivo studies for you.

Our virologists are experienced with every stage of antiviral and vaccine development, including propagating viruses, determining viral titres and testing the efficacy of your antivirals. We use cell culture viability assays and plaque assays to test lead compounds as part of in vitro viral screening programmes or in support of in vivo models.

In vivo viral and bacterial disease studies

At KWS BioTest we use a suite of methods to improve your understanding of disease, host interactions and treatment effects. We measure disease using conventional CFU (colony-forming-units) or viral titre assessments and combine these with clinical disease parameters and PD (pharmacodynamic) analysis.

In addition, using protocols pioneered at KWS BioTest, we have the ability to provide data from real-time in vivo bioluminescent imaging, allowing you to follow the course of the disease and its treatment.

A broad range of clinically relevant Gram-positive and Gram-negative species can be used in both proof of concept PD models and in specialized translational human disease models, all of which can be adapted to run with strains of your choice. These include:

  • Thigh infection
  • Sepsis
  • Lung infection
  • Skin infection (acute and chronic biofilm models)
  • Urinary Tract Infections
  • Vaginal carriage
  • Clostridium difficile infection

Specialist viral infection models can be used in order to test your anti-virals and vaccines. These include:

  • Influenza (current and experimental strains)
  • Herpes Simplex Virus
  • Respiratory Syncytial Virus

We are continually adding to our portfolio of infection models, so please get in touch with us to discuss how we can help you.

KWS BioTest expertise in infection provides insight into your antimicrobial programme.

KWS BioTest uses IVIS (in vivo imaging system) technology to provide real-time, non–invasive imaging of anti-infective efficacy in vivo.